Mainland France is part of a plate interior with a strong structural heritage, undergoing a low rate of deformation, where destructive earthquakes can nevertheless occur. In this paper, we emphasize that the knowledge of active faults is still largely fragmentary, and that significant efforts are needed to generate robust data, in particular on the numerous faults, that still lack any study. This is the aim of the “Failles ACTives France” (FACT) axis launched in the framework of the Transverse Seismicity Action (ATS) of the Resif-Epos consortium. We present some recent investigations carried out along suspected active faults in mountainous areas, their forelands and remote lowlands, which implement new approaches and new tools, and allow characterizing their Quaternary activity.