The review of recent bathymetric and geophysical data collected in the framework of several research and cartographic projects have allowed a detailed reconstruction of the morpho-structural setting and the (neo)tectonic evolution for both the Alpine and Apennine margins of the Ligurian Sea (Italy). The widespread occurrence of erosional processes and sediment mass movements along the steep continental slope and within the system of submarine canyons reflect the close correlation between the active tectonics and the recent morpho-dynamic evolution of the Ligurian Margin. This relation is better constrained in the western sector (Alpine) of the Ligurian Sea, where the recent uplift of the continental margin is associated to a well-developed system of inherited structures reactivated under a compressive/transpressive regime and widespread seismicity. In the eastern sector, where the seismicity is lower or absent, the mass movements are limited to few areas (e.g., the Portofino slope) coinciding with seismic clusters. Additionally, this sector is characterized by moderate and episodic fault reactivations under a compressive regime. The evidence of compressive deformation along the inherited fault systems has been revealed in some areas of the Ligurian Sea where the post-drifting extensional tectonics is interrupted by episodic tectonic inversion (at least) during the Middle–Upper Miocene and the Plio–Pleistocene until present.