The Anthropocene, defined by human-induced environmental transformations, presents a critical challenge: plastic pollution. This complex problem, particularly prominent in coastal and marine environments, requires integrated and adaptive responses. This opinion paper examines global efforts across policy interventions, scientific innovations, and public education, highlighting both advancements and hurdles in managing this problem. These include enforcement limitations in policy implementation, scalability and cost issues in scientific innovations, and challenges in effecting large-scale behavioral change through public education. The complexities inherent in managing plastic litter in coastal and marine environments are further discussed, emphasizing the necessity for an integrated approach. This approach involves interdisciplinary collaboration, adaptive management, stakeholder engagement, policy integration, sustainable financing, resilience building, capacity enhancement, technological innovation, policy reform, ecosystem-based management, disaster risk reduction, and advocacy. The management of plastic pollution in the Anthropocene requires strategic planning, innovative thinking, and unified global efforts, ultimately providing an opportunity to redefine our relationship with the planet and steer toward a more sustainable future.