How do gravity alterations affect animal and human systems at a cellular/tissue level?
Type | Article | ||||||||||||
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Date | 2023-10 | ||||||||||||
Language | English | ||||||||||||
Author(s) | Cialdai Francesca1, Brown Austin M.2, Baumann Cory W.3, Angeloni Debora4, Baatout Sarah5, Benchoua Alexandra6, Bereiter-Hahn Juergen7, Bottai Daniele8, Buchheim Judith-Irina9, Calvaruso Marco10, Carnero-Diaz Eugénie11, Castiglioni Sara12, Cavalieri Duccio13, Ceccarelli Gabriele14, Choukér Alexander9, Ciofani Gianni15, Coppola Giuseppe16, Cusella Gabriella14, Degl’innocenti Andrea17, 18, Desaphy Jean-Francois19, Frippiat Jean-Pol20, Gelinsky Michael21, Genchi Giada15, Grano Maria19, Grimm Daniela22, 23, Guignandon Alain24, Hahn Christiane25, Hatton Jason25, Herranz Raúl26, Hellweg Christine E.27, Iorio Carlo Saverio28, Karapantsios Thodoris29, Van Loon Jack30, Lulli Matteo31, Maier Jeanette12, Malda Jos32, Mamaca Emina33, Morbidelli Lucia34, Van Ombergen Angelique25, Osterman Andreas35, Ovsianikov Aleksandr36, Pampaloni Francesco37, Pavezlorie Elizabeth38, Pereda-Campos Veronica39, Przybyla Cyrille40, Puhl Christopher41, Rettberg Petra42, Risaliti Chiara1, Rizzo Angela Maria43, Robson-Brown Kate44, Rossi Leonardo45, Russo Giorgio10, Salvetti Alessandra45, Santucci Daniela46, Sperl Matthias47, Strollo Felice48, Tabury Kevin5, Tavella Sara49, Thielemann Christiane50, Willaert Ronnie51, Szewczyk Nathaniel J.3, Monici Monica1 | ||||||||||||
Affiliation(s) | 1 : ASAcampus Joint Laboratory, ASA Res. Div., DSBSC-University of Florence, Florence, Italy 2 : Honors Tutorial College, Ohio University, Athens, OH, USA 3 : Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA 4 : Inst. of Biorobotics, Scuola Superiore Sant’Anna, Pisa, Italy 5 : Radiobiology Unit, Belgian Nuclear Research Centre (SCK CEN) Boeretang 200, 2400, Mol, Belgium 6 : ISTEM, CECS, AFM-Téléthon, Corbeil-Essonnes, France 7 : Inst. for Cell and Neurobiol, Goethe University Frankfurt am Main, Frankfurt am Main, Germany 8 : Dept. Pharmaceutical Sciences, University of Milan, Milan, Italy 9 : Laboratory of “Translational Research, Stress & Immunity”, Department of Anesthesiology, LMU University Hospital Munich, Munich, Germany 10 : Inst. Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Cefalù, Italy 11 : Inst. Systematic, Evolution, Biodiversity, Sorbonne University, NMNH, CNRS, EPHE, UA, Paris, France 12 : Dept. of Biomedical and Clinical Sciences, University of Milan, Milan, Italy 13 : Dept. of Biology, University of Florence, Florence, Italy 14 : Dept of Public Health, Experimental Medicine and Forensic, University of Pavia, Pavia, Italy 15 : Smart Bio-Interfaces, Istituto Italiano di Tecnologia, 56025, Pontedera (PI), Italy 16 : Institute of Applied Science and Intelligent Sistems – CNR, Naples, Italy 17 : Dept Medical Biotechnologies, University of Siena, Siena, Italy 18 : Smart Bio-Interfaces, IIT, Pontedera (PI), Italy 19 : Dept. Precision and Regenerative Medicine, University of Bari “Aldo Moro”, Bari, Italy 20 : Stress, Immunity, Pathogens Laboratory, SIMPA, Université de Lorraine, Nancy, France 21 : Centre for Translational Bone, Joint & Soft Tissue Research, TU Dresden, Dresden, Germany 22 : Dept. Microgravity and Translational Regenerative Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany 23 : Dept of Biomedicine, Aarhus University, Aarhus, Denmark 24 : SAINBIOSE, INSERM U1059, Université Jean Monnet, F-42000, Saint-Etienne, France 25 : European Space Agency, Paris, France 26 : Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain 27 : Radiation Biology Dept., Inst. of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany 28 : CREST-ATM, Université libre de Bruxelles, Bruxelles, Belgium 29 : Faculty of Chemistry, Aristotle Univeristy of Thessaloniki, Thessaloniki, Greece 30 : Amsterdam University Medical Center, ACTA/VU, Amsterdam, The Netherlands 31 : Dept. Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy 32 : Dept. Orthopaedics, Univ. Med. Center Utrecht & Dept. Clinical Sciences, Utrecht Univ, Utrecht, The Netherlands 33 : European and International Affairs Dept, Ifremer centre Bretagne, Plouzané, France 34 : Dept. Life Sciences, Univ. of Siena, Siena, Italy 35 : Max von Pettenkofer Institute, Virology, LMU Munich & DZIF, Partner Site Munich, Munich, Germany 36 : 3D Printing and Biofabrication, Inst. Materials Science and Technology, TU Wien, Vienna, Austria 37 : Buchmann Inst. for Molecular Life Sciences, Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany 38 : Ludwig Boltzmann Inst. for Traumatology, Res. Center in Cooperation with AUVA, Vienna, Austria 39 : GSBMS/URU EVOLSAN - Medecine Evolutive, Université Paul Sabatier Toulouse III, Toulouse, France 40 : MARBEC, Univ Montpellier, CNRS, Ifremer, IRD, Palavas les Flots, France 41 : Space Applications NV/SA for European Space Agency, Houston, USA 42 : DLR, Inst of Aerospace Medicine, Research Group Astrobiology, Köln, Germany 43 : Dept. of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy 44 : Dept of Engineering Mathematics, and Dept of Anthropology and Archaeology, University of Bristol, Bristol, UK 45 : Dept. Clinical and Experimental Medicine, University of Pisa, Pisa, Italy 46 : Center for Behavioural Sciences and Mental Health, Ist. Superiore Sanità, Rome, Italy 47 : DLR-MP, Cologne, Germany 48 : Endocrinology and Metabolism Unit, IRCCS San Raffaele Pisana, Rome, Italy 49 : IRCCS Ospedale Policlinico San Martino and University of Genoa, DIMES, Genoa, Italy 50 : BioMEMS lab, University of Applied Sciences Aschaffenburg, Aschaffenburg, Germany 51 : Research Group NAMI and NANO, Vrije Universiteit Brussels, Brussels, Belgium |
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Source | Npj Microgravity (2373-8065) (Springer Science and Business Media LLC), 2023-10 , Vol. 9 , N. 1 , P. 84 (9p.) | ||||||||||||
DOI | 10.1038/s41526-023-00330-y | ||||||||||||
WOS© Times Cited | 2 | ||||||||||||
Abstract | The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?” This is one of the five major scientific issues of the ESA roadmap “Biology in Space and Analogue Environments”. Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects. |
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