How do gravity alterations affect animal and human systems at a cellular/tissue level?

The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?” This is one of the five major scientific issues of the ESA roadmap “Biology in Space and Analogue Environments”. Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects.

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Cialdai Francesca, Brown Austin M., Baumann Cory W., Angeloni Debora, Baatout Sarah, Benchoua Alexandra, Bereiter-Hahn Juergen, Bottai Daniele, Buchheim Judith-Irina, Calvaruso Marco, Carnero-Diaz Eugénie, Castiglioni Sara, Cavalieri Duccio, Ceccarelli Gabriele, Choukér Alexander, Ciofani Gianni, Coppola Giuseppe, Cusella Gabriella, Degl’innocenti Andrea, Desaphy Jean-Francois, Frippiat Jean-Pol, Gelinsky Michael, Genchi Giada, Grano Maria, Grimm Daniela, Guignandon Alain, Hahn Christiane, Hatton Jason, Herranz Raúl, Hellweg Christine E., Iorio Carlo Saverio, Karapantsios Thodoris, Van Loon Jack, Lulli Matteo, Maier Jeanette, Malda Jos, Mamaca Emina, Morbidelli Lucia, Van Ombergen Angelique, Osterman Andreas, Ovsianikov Aleksandr, Pampaloni Francesco, Pavezlorie Elizabeth, Pereda-Campos Veronica, Przybyla Cyrille, Puhl Christopher, Rettberg Petra, Risaliti Chiara, Rizzo Angela Maria, Robson-Brown Kate, Rossi Leonardo, Russo Giorgio, Salvetti Alessandra, Santucci Daniela, Sperl Matthias, Strollo Felice, Tabury Kevin, Tavella Sara, Thielemann Christiane, Willaert Ronnie, Szewczyk Nathaniel J., Monici Monica (2023). How do gravity alterations affect animal and human systems at a cellular/tissue level?. Npj Microgravity. 9 (1). 84 (9p.).,

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