How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Type Article
Date 2024-02
Language English
Author(s) Davis TrentORCID1, Tabury KevinORCID2, Zhu Shouan1, Angeloni Debora3, Baatout SarahORCID2, Benchoua Alexandra4, Bereiter-Hahn Juergen5, Bottai DanieleORCID6, Buchheim Judith-Irina7, Calvaruso Marco8, Carnero-Diaz Eugénie9, Castiglioni Sara10, Cavalieri DuccioORCID11, Ceccarelli Gabriele12, Choukér AlexanderORCID7, Cialdai Francesca13, Ciofani GianniORCID14, Coppola Giuseppe15, Cusella Gabriella12, Degl’innocenti Andrea16, Desaphy Jean-FrancoisORCID17, Frippiat Jean-PolORCID18, Gelinsky MichaelORCID19, Genchi Giada14, Grano Maria17, Grimm DanielaORCID20, Guignandon Alain21, Hahn Christiane22, Hatton Jason22, Herranz RaúlORCID23, Hellweg Christine E.ORCID24, Iorio Carlo Saverio25, Karapantsios ThodorisORCID26, Van Loon Jack J.W.A.ORCID27, Lulli MatteoORCID28, Maier Jeanette10, Malda Jos29, Mamaca Emina30, Morbidelli Lucia31, Van Ombergen Angelique22, Osterman Andreas32, Ovsianikov AleksandrORCID33, Pampaloni FrancescoORCID34, Pavezlorie Elizabeth35, Pereda-Campos Veronica36, Przybyla CyrilleORCID37, Puhl Christopher38, Rettberg PetraORCID39, Rizzo Angela MariaORCID40, Robson-Brown Kate41, Rossi Leonardo42, Russo Giorgio8, Salvetti Alessandra42, Santucci DanielaORCID43, Sperl MatthiasORCID44, Tavella SaraORCID45, Thielemann ChristianeORCID46, Willaert RonnieORCID47, Szewczyk NathanielORCID1, Monici MonicaORCID13
Affiliation(s) 1 : Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA
2 : Laboratory of Radiobiology, Belgian Nuclear Research Centre, SCK CEN, Mol, Belgium
3 : Institute of Biorobotics, Scuola Superiore Sant’Anna, Pisa, Italy
4 : ISTEM, CECS, AFM-Téléthon, Corbeil-Essonnes, France
5 : Institute for Cell Biology and Neurobiology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
6 : Department Pharmaceutical Sciences, University of Milan, Milan, Italy
7 : Laboratory of “Translational Research, Stress & Immunity”, Department of Anesthesiology, LMU University Hospital Munich, Munich, Germany
8 : Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Cefalù, Italy
9 : Institute of Systematics, Evolution, Biodiversity, Sorbonne University, NMNH, CNRS, EPHE, UA, Paris, France
10 : Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy
11 : Department of Biology, University of Florence, Florence, Italy
12 : Department of Public Health, Experimental Medicine and Forensic, University of Pavia, Pavia, Italy
13 : ASAcampus Joint Laboratory, ASA Research Division, DSBSC-University of Florence, Florence, Italy
14 : Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Pontedera, PI, 56025, Italy
15 : Institute of Applied Science and Intelligent Systems – CNR, Naples, Italy
16 : Department of Medical Biotechnologies, University of Siena, Italy and Smart Bio-Interfaces, IIT, Pontedera, PI, Italy
17 : Department of Precision and Regenerative Medicine, University of Bari “Aldo Moro”, Bari, Italy
18 : Stress, Immunity, Pathogens Laboratory, SIMPA, Université de Lorraine, Nancy, France
19 : Centre for Translational Bone, Joint & Soft Tissue Research, TU Dresden, Dresden, Germany
20 : Department of Microgravity and Translational Regenerative Medicine, Otto-von-Guericke-University Magdeburg, Germany & Dept of Biomedicine, Aarhus University, Aarhus, Denmark
21 : SAINBIOSE, INSERM U1059, Université Jean Monnet, Saint-Etienne, F-42000, France
22 : European Space Agency, ESTEC, Noordwijk, The Netherlands
23 : Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain
24 : Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany
25 : CREST-ATM, Université libre de Bruxelles, Bruxelles, Belgium
26 : Faculty of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
27 : Amsterdam University Medical Center, ACTA/VU, Amsterdam, Netherlands
28 : Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
29 : Department of Orthopaedics, University Medical Center Utrecht & Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands
30 : European and International Affairs Department, Ifremer centre Bretagne, Plouzané, France
31 : Department of Life Sciences, University of Siena, Siena, Italy
32 : Max von Pettenkofer Institute, Virology, LMU Munich & DZIF, Partner Site Munich, Munich, Germany
33 : D Printing and Biofabrication, Institute of Materials Science and Technology, TU Wien, Vienna, Austria
34 : Buchmann Inst. for Molecular Life Sciences, Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany
35 : Ludwig Boltzmann Institute for Traumatology, Research Center in Cooperation with AUVA, Vienna, Austria
36 : GSBMS/URU EVOLSAN - Medecine Evolutive, Université Paul Sabatier Toulouse III, Toulouse, France
37 : MARBEC, Université de Montpellier, CNRS, Ifremer, IRD, Palavas les Flots, France
38 : Space Applications NV/SA for European Space Agency, Noordwijk, The Netherlands
39 : DLR, Institute of Aerospace Medicine, Research Group Astrobiology, Köln, Germany
40 : Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
41 : Department of Engineering Mathematics, and Department of Anthropology and Archaeology, University of Bristol, Bristol, UK
42 : Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
43 : Center for Behavioural Sciences and Mental Health, Istituto Superiore Sanità, Rome, Italy
44 : DLR-MP, Cologne, Germany
45 : IRCCS Ospedale Policlinico San Martino and University of Genoa, DIMES, Genoa, Italy
46 : BioMEMS lab, University of Applied Sciences Aschaffenburg, Aschaffenburg, Germany
47 : Research Group NAMI and NANO, Vrije Universiteit Brussels, Brussels, Belgium
Source Npj Microgravity (2373-8065) (Springer Science and Business Media LLC), 2024-02 , Vol. 10 , N. 1 , P. 16 (7p.)
DOI 10.1038/s41526-024-00357-9
Abstract

Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.
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Davis Trent, Tabury Kevin, Zhu Shouan, Angeloni Debora, Baatout Sarah, Benchoua Alexandra, Bereiter-Hahn Juergen, Bottai Daniele, Buchheim Judith-Irina, Calvaruso Marco, Carnero-Diaz Eugénie, Castiglioni Sara, Cavalieri Duccio, Ceccarelli Gabriele, Choukér Alexander, Cialdai Francesca, Ciofani Gianni, Coppola Giuseppe, Cusella Gabriella, Degl’innocenti Andrea, Desaphy Jean-Francois, Frippiat Jean-Pol, Gelinsky Michael, Genchi Giada, Grano Maria, Grimm Daniela, Guignandon Alain, Hahn Christiane, Hatton Jason, Herranz Raúl, Hellweg Christine E., Iorio Carlo Saverio, Karapantsios Thodoris, Van Loon Jack J.W.A., Lulli Matteo, Maier Jeanette, Malda Jos, Mamaca Emina, Morbidelli Lucia, Van Ombergen Angelique, Osterman Andreas, Ovsianikov Aleksandr, Pampaloni Francesco, Pavezlorie Elizabeth, Pereda-Campos Veronica, Przybyla Cyrille, Puhl Christopher, Rettberg Petra, Rizzo Angela Maria, Robson-Brown Kate, Rossi Leonardo, Russo Giorgio, Salvetti Alessandra, Santucci Daniela, Sperl Matthias, Tavella Sara, Thielemann Christiane, Willaert Ronnie, Szewczyk Nathaniel, Monici Monica (2024). How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms? Npj Microgravity, 10(1), 16 (7p.). Publisher's official version : https://doi.org/10.1038/s41526-024-00357-9 , Open Access version : https://archimer.ifremer.fr/doc/00877/98860/