The Namib Sand Sea (NSS) in Namibia is known to preserve a wide variety of Pleistocene-age archaeological sites. However, few Middle Stone Age (MSA) sites in this region have been systematically investigated and basic questions around chronology and technological organization remain open. Here we examine Narabeb, an open air MSA surface site exposed in an interdune pan, ∼30 km into the northern NSS. Narabeb was first documented in the 1970s, and then re-examined in 2021 and 2022 by members of this team. Lithic technological analysis combined with a geomorphological description of the site, palaeoenvironmental interpretation of fine-grain water-lain sediments, and luminescence ages from northern and southern locations on the Narabeb pan provide some of the first understanding of human-environmental interactions and estimates of chronology from the later-Middle and Late Pleistocene in the NSS. In addition, we apply a quantitative approach to aeolian linear dune accumulation and extension to explore possible scenarios for landscape development at this site, in order to better understand the former water course(s) affecting the area. The new chronology suggests this site contained standing water at, or just after, the MIS 7/6 transition, and again at, or just after, the end of MIS 6 into early MIS 5. The timing of greater phases of water availability have some overlap with the speleothem growth record at Rössing Cave, situated ∼90 km north of the NSS (and ∼135 km north of Narabeb). Our results provide the foundation for larger, regional-scale analyses of early human adaptive strategies in this unique environment within Southern Africa.