The Cotentin Peninsula (CP) is one of the only area in Europe which contains records of a > 2.5 Ga-lasted geological history including three orogenic events (Archaean, Cadomian and Variscan) followed by a polyphase basin/inversion evolution during Meso-Cenozoic times. The CP area sensu lato is thus a suitable place for discussing how the structural configuration of the basement might have influenced the development of part of the southern shelf margin of the Central English Channel, even if sediments and post-Variscan tectonic records are limited at this place. This issue is addressed through an onshore/offshore structural approach combining newly-acquired high resolution bathymetric data and reflection seismic profiles, further constrained by lateral correlations onshore. The resulting Land-Sea Digital Elevation Model and corresponding geological map reveal a number of fault-bounded blocks involving a relatively thin package of Jurassic to Plio-Quaternary sequences, locally involved in slightly compressional deformations. These specific sedimentary and tectonic features typically characterize the southern shelf margin of the Central English Channel. They are discussed in terms of basin development and inversion processes in relation with basement structures and then integrated in the English Channel basin framework. Special attention is paid to three major structural features, i.e. the La Hague Offshore Fault, the La Hague Deep Fault network and the La Hague Deep, which emphasize, respectively, the role of structural inheritance and erosion/incision/deposition events during the post-Variscan tectono-sedimentary history of the southern elevated shoulder of the Central English Channel