Conservation measures are implemented to support biodiversity in areas that are degraded or under anthropogenic pressure. Over the past decade, numerous projects aimed at rehabilitating a fish nursery function in ports, through the installation of artificial structures, have emerged. While studies conducted on these solutions seem promising on a very local scale (e.g., higher densities of juvenile fish on artificial fish nurseries compared to bare port infrastructures), no evaluation has been undertaken yet to establish their contribution to the renewal of coastal fish populations or their performance compared to other conservation measures such as fishing regulation. Here, we used a coupled model of fish population dynamics and fisheries management, ISIS-fish, to describe the coastal commercial fish population, the white seabream (Diplodus sargus) in the highly artificialized Bay of Toulon. Using ISIS-Fish, we simulated rehabilitation and fisheries management scenarios. We provided the first quantitative assessment of the implementation of artificial structures in ports covering 10% and 100% of the available port area and compared, at population level and fishing fleets level, the quantitative consequences of these rehabilitation measures with fishing control measures leading to strict compliance with minimum catch sizes. The rehabilitation of the nursery function in ports demonstrated a potential to enhance the renewal of fish populations and catches. When the size of projects is small the outcomes they provide remain relatively modest in contrast to the impact of regulatory fishing measures. However, we have demonstrated that combining fishing reduction measures and rehabilitation projects has a synergistic effect on fish populations, resulting in increased populations and catches. This study is the first quantitative assessment of fish nursery rehabilitation projects in port areas, by evaluating their effectiveness in renewing coastal fish populations and fisheries and comparing their outcomes with fishing control measures. Small-scale port-area nursery rehabilitation projects can support fish populations, but are less effective than controlling fisheries.