Paleobathymetric reconstructions suggest that 35 million years ago, local uplift of the Davie Ridge could have temporarily raised a continental land-bridge between Africa and Madagascar and dramatically affected their connectivity. Numerical simulations of a regional model of the southwest Indian Ocean at mesoscale resolution are performed to investigate the consequences of such a closure of the Mozambique Channel. Compared to a reference simulation of present day circulation, blocking the Mozambique Channel results in a redistribution of the transport around Madagascar dramatically strengthening the East Madagascar Current and eddy variability south of Madagascar, broadening the Agulhas Current, and modifying water mass properties and bottom circulation.