To comply with the demanding operational conditions of seawater reverse osmosis (SWRO) process, both in terms of corrosion resistance and mechanical properties, the conventional metallic material selection was often stainless steel for seawater and brines handling units (e.g. pumps, valves and piping). However, many cases of corrosion failures of stainless steel in SWRO desalination units have been reported often attributed to un-adapted stainless steel grade selection and/or to the particular aggressive conditions in “warm” regions where many recent desalination plants are built (high ambient temperature, severe biofouling, etc.). The operational corrosion risk will actually highly depend on the material composition, on the metallurgy (i.e. cast or wrought), on the service conditions and on the geometrical configuration of the concerned units in contact with seawater. Considering all these parameters, a proper material selection should avoid corrosion issue. For existing corrosion, cathodic protection (CP) may be an efficient solution to stop or to control the propagation of the degradation. However, the CP for materials used in SWRO desalination plants and in its specific operational conditions (i.e. high pressure, velocity and confinements) is not well documented; as a result, an adapted CP design is not always possible from existing data. The present paper reviews some corrosion cases of stainless steel and copper-based alloys in SWRO desalination plants. Solutions to manage existing corrosion of metallic materials in SWRO plants are discussed and focus is done on CP of stainless steel elements. Some results of an ongoing investigation about the CP for the specific operational conditions of SWRO desalination plant are presented and discussed.