||Munschy Catherine1, Moisan Karine1, Tixier Celine1, Pacepavicius G.2, Alaee M.2
||1 : Inst Francais Rech Exploitat Mer IFREMER, Lab Biogeochem Organ Contaminants, F-44311 Nantes 3, France.
2 : Environm Canada, Aquat Ecosyst Protect Res Div, Burlington, ON L7R 4A6, Canada.
||Environmental Pollution (0269-7491) (Elsevier Sci Ltd), 2010-12 , Vol. 158 , N. 12 , P. 3527-3533
|WOS© Times Cited
||Marine flatfish, PBDEs, Bioaccumulation, Biotransformation, Hydroxylated metabolites
||The uptake, elimination and transformation of six PBDE congeners (BDE-28, -47, -99, -100, -153, -209) were studied in juvenile common sole (Solea solea L) exposed to spiked contaminated food over a three-month period, and then depurated over a five-month period. Methoxylated (MeO-) and hydroxylated (OH-) PBDEs were determined in fish plasma exposed to PBDEs and compared to those obtained in control fish. While all MeO- and some OH- congeners identified in fish plasma were found to originate from non-metabolic sources, several OH- congeners, i.e., OH-tetraBDEs and OH-pentaBDEs, were found to originate from fish metabolism. Among these, 4 '-OH-BDE-49 was identified as a BDE-47 metabolite. Congener 4 '-OH-BDE-101, identified here for the first time, may be the result of BDE-99 metabolic transformation. Our results unequivocally showed that PBDEs are metabolised in juvenile sole via the formation of OH- metabolites. However, this was not a major biotransformation route compared to biotransformation through debromination. (C) 2010 Elsevier Ltd. All rights reserved.
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