Phylodynamics and human-mediated dispersal of a zoonotic virus.
| Type | Article | ||||||||
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| Date | 2010 | ||||||||
| Language | English | ||||||||
| Author(s) | Talbi Chiraz1, Lemey Philippe2, Suchard Marc A.3, Abdelatif Elbia4, Elharrak Mehdi5, Nourlil Jalal6, Abdellah Faouzi6, Echevarria Juan E.7, Moron Sonia Vasquez7, Rambaut Andrew8, 9, Campiz Nicholas10, Tatem Andrew J.10, 11, Holmes Edward9, 12, Bourhy Hervé1 | ||||||||
| Affiliation(s) | 1 : Institut Pasteur, Unit Lyssavirus Dynamics and Host Adaptation, WHO Collaborating Centre for Reference and Research on Rabies, Paris, France 2 : Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium 3 : Departments of Biomathematics and Human Genetics, David Geffen School of Medicine, and Department of Biostatistics, School of Public Health, University of California, Los Angeles, Los Angeles, California, United States of America 4 : Institut Pasteur d’Alge´ rie, Laboratoire de la Rage, Recherche et Diagnostic, Alger, Alge´ rie 5 : Biopharma Laboratoire, Rabbat, Maroc 6 : Institut Pasteur du Maroc, Laboratoire de Virologie Me´dicale, Casablanca, Maroc 7 : Instituto de Salud Carlos III, Servicio de Microbiologı´a Diagno´ stica, Madrid, Spain 8 : of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom 9 : Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America 10 : Department of Geography, University of Florida, Gainesville, Florida, United States of America 11 : Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America 12 : Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America |
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| Source | PLOS pathogens (1553-7374) (Public Library Science), 2010 , Vol. 6 , N. 10 , P. 1-10 | ||||||||
| DOI | 10.1371/journal.ppat.1001166 | ||||||||
| Abstract | Understanding the role of humans in the dispersal of predominately animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (RABV) in North Africa. Each of the countries studied exhibited largely disconnected spatial dynamics with major geo-political boundaries acting as barriers to gene flow. Road distances proved to be better predictors of the movement of dog RABV than accessibility or raw geographical distance, with occasional long distance and rapid spread within each of these countries. Using simulations that bridge phylodynamics and spatial epidemiology, we demonstrate that the contemporary viral distribution extends beyond that expected for RABV transmission in African dog populations. These results are strongly supportive of human-mediated dispersal, and demonstrate how an integrated phylogeographic approach will turn viral genetic data into a powerful asset for characterizing, predicting, and potentially controlling the spatial spread of pathogens | ||||||||
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