|Author(s)||Thebault Anne1, Teunis Peter F. M.2, 3, Le Pendu Jacques4, 5, 6, Le Guyader Soizick7, Denis Jean-Baptiste8|
|Affiliation(s)||1 : ANSES, F-94701 Maisons Alfort, France.
2 : Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
3 : Rollins Sch Publ Hlth, Atlanta, GA USA.
4 : INSERM, Nantes, France.
5 : Univ Nantes, Nantes, France.
6 : CNRS, Nantes, France.
7 : IFREMER, Nantes, France.
8 : INRA, Jouy En Josas, France.
|Source||Epidemics (1755-4365) (Elsevier Science Bv), 2013-06 , Vol. 5 , N. 2 , P. 98-110|
|WOS© Times Cited||54|
|Keyword(s)||Norovirus, Shellfish, Bayesian analysis, Dose-response relationship, Fucosyltransferases|
|Abstract||Noroviruses (NoVs) are the major cause of acute epidemic gastroenteritis in industrialized countries. Outbreak strains are predominantly genogroup II (GII) NoV, but genogroup I (GI) strains are regularly found in oyster related outbreaks. The prototype Norwalk virus (GI), has been shown to have high infectivity in a human challenge study. Whether other NoVs are equally infectious via natural exposure remains to be established. Human susceptibility to NoV is partly determined by the secretor status (Se+/-). Data from five published oyster related outbreaks were analyzed in a Bayesian framework. Infectivity estimates where high and consistent with NV(GI) infectivity, for both GII and GI strains. The median and CI95 probability of infection and illness, in Se+ subjects, associated with exposure to a mean of one single NoV genome copy were around 0.29[0.015-0.61] for GI and 0.4[0.04-0.61] for GII, and for illness 0.13[0.007-0.39] for GI and 0.18[0.017-0.42] for GII. Se-subjects were strongly protected against infection. The high infectivity estimates for Norwalk virus GI and GII, makes NoVs critical target for food safety regulations.|
Thebault Anne, Teunis Peter F. M., Le Pendu Jacques, Le Guyader Soizick, Denis Jean-Baptiste (2013). Infectivity of GI and GII noroviruses established from oyster related outbreaks. Epidemics, 5(2), 98-110. Publisher's official version : https://doi.org/10.1016/j.epidem.2012.12.004 , Open Access version : https://archimer.ifremer.fr/doc/00148/25927/