Infectivity of GI and GII noroviruses established from oyster related outbreaks

Type Article
Date 2013-06
Language English
Author(s) Thebault Anne1, Teunis Peter F. M.2, 3, Le Pendu Jacques4, 5, 6, Le Guyader Soizick7, Denis Jean-Baptiste8
Affiliation(s) 1 : ANSES, F-94701 Maisons Alfort, France.
2 : Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
3 : Rollins Sch Publ Hlth, Atlanta, GA USA.
4 : INSERM, Nantes, France.
5 : Univ Nantes, Nantes, France.
6 : CNRS, Nantes, France.
7 : IFREMER, Nantes, France.
8 : INRA, Jouy En Josas, France.
Source Epidemics (1755-4365) (Elsevier Science Bv), 2013-06 , Vol. 5 , N. 2 , P. 98-110
DOI 10.1016/j.epidem.2012.12.004
WOS© Times Cited 56
Keyword(s) Norovirus, Shellfish, Bayesian analysis, Dose-response relationship, Fucosyltransferases
Abstract Noroviruses (NoVs) are the major cause of acute epidemic gastroenteritis in industrialized countries. Outbreak strains are predominantly genogroup II (GII) NoV, but genogroup I (GI) strains are regularly found in oyster related outbreaks. The prototype Norwalk virus (GI), has been shown to have high infectivity in a human challenge study. Whether other NoVs are equally infectious via natural exposure remains to be established. Human susceptibility to NoV is partly determined by the secretor status (Se+/-). Data from five published oyster related outbreaks were analyzed in a Bayesian framework. Infectivity estimates where high and consistent with NV(GI) infectivity, for both GII and GI strains. The median and CI95 probability of infection and illness, in Se+ subjects, associated with exposure to a mean of one single NoV genome copy were around 0.29[0.015-0.61] for GI and 0.4[0.04-0.61] for GII, and for illness 0.13[0.007-0.39] for GI and 0.18[0.017-0.42] for GII. Se-subjects were strongly protected against infection. The high infectivity estimates for Norwalk virus GI and GII, makes NoVs critical target for food safety regulations.
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