Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells

Type Article
Date 2013-11
Language English
Author(s) Baudelet Paul-Hubert1, Gagez Anne-Laure1, 2, Berard Jean-BaptisteORCID3, Juin Camille1, Bridiau Nicolas1, Kaas Raymond3, Thiery Valerie1, Cadoret Jean-Paul3, Picot Laurent1
Affiliation(s) 1 : Univ La Rochelle, UMRi CNRS LIENSs 7266, F-17042 La Rochelle, France.
2 : Univ La Rochelle, UMRi CNRS LIENSs 7266, F-17071 La Rochelle 9, France.
3 : IFREMER Ctr Nantes, IFREMER, Lab PBA, F-44311 Nantes, France.
Source Marine Drugs (1660-3397) (Mdpi Ag), 2013-11 , Vol. 11 , N. 11 , P. 4390-4406
DOI 10.3390/md11114390
WOS© Times Cited 32
Keyword(s) pigments, microalgae, Cyanophora paradoxa, melanoma, cancer, apoptosis, zeaxanthin, cryptoxanthin
Abstract The glaucophyte Cyanophora paradoxa (Cp) was chemically investigated to identify pigments efficiently inhibiting malignant melanoma, mammary carcinoma and lung adenocarcinoma cells growth. Cp water and ethanol extracts significantly inhibited the growth of the three cancer cell lines in vitro, at 100 mu g.mL(-1). Flash chromatography of the Cp ethanol extract, devoid of c-phycocyanin and allophycocyanin, enabled the collection of eight fractions, four of which strongly inhibited cancer cells growth at 100 mu g.mL(-1). Particularly, two fractions inhibited more than 90% of the melanoma cells growth, one inducing apoptosis in the three cancer cells lines. The detailed analysis of Cp pigment composition resulted in the discrimination of 17 molecules, ten of which were unequivocally identified by high resolution mass spectrometry. Pheophorbide a, beta-cryptoxanthin and zeaxanthin were the three main pigments or derivatives responsible for the strong cytotoxicity of Cp fractions in cancer cells. These data point to Cyanophora paradoxa as a new microalgal source to purify potent anticancer pigments, and demonstrate for the first time the strong antiproliferative activity of zeaxanthin and beta-cryptoxanthin in melanoma cells.
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Baudelet Paul-Hubert, Gagez Anne-Laure, Berard Jean-Baptiste, Juin Camille, Bridiau Nicolas, Kaas Raymond, Thiery Valerie, Cadoret Jean-Paul, Picot Laurent (2013). Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells. Marine Drugs, 11(11), 4390-4406. Publisher's official version : , Open Access version :