Tulane Virus as a Potential Surrogate To Mimic Norovirus Behavior in Oysters

Type Article
Date 2015-08
Language English
Author(s) Drouaz Najoua1, Schaeffer Julien1, Farkas Tibor2, Le Pendu Jacques3, Le Guyader Soizick1
Affiliation(s) 1 : IFREMER, Lab Microbiol, LSEM SG2M, Nantes, France.
2 : Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Lab Specialized Clin Studies, Cincinnati, OH 45229 USA.
3 : Univ Nantes, INSERM, CNRS, U892,UMR6299, Nantes, France.
Source Applied And Environmental Microbiology (0099-2240) (Amer Soc Microbiology), 2015-08 , Vol. 81 , N. 15 , P. 5249-5256
DOI 10.1128/AEM.01067-15
WOS© Times Cited 17
Abstract Oyster contamination by noroviruses is an important health and economic problem. The present study aimed to compare the behaviors of Norwalk virus (the prototype genogroup I norovirus) and two culturable viruses: Tulane virus and mengovirus. After bioaccumulation, tissue distributions were quite similar for Norwalk virus and Tulane virus, with the majority of viral particles detected in digestive tissues, while mengovirus was detected in large amounts in the gills and mantle as well as in digestive tissues. The levels of persistence of all three viruses over 8 days were comparable, but clear differences were observed over longer periods, with Norwalk and Tulane viruses displaying rather similar half-lives, unlike mengovirus, which was cleared more rapidly. These results indicate that Tulane virus may be a good surrogate for studying norovirus behavior in oysters, and they confirm the prolonged persistence of Norwalk virus in oyster tissues.
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