Transition from Environmental to Partial Genetic Sex Determination in Daphnia through the Evolution of a Female-Determining Incipient W Chromosome

Type Article
Date 2017-03
Language English
Author(s) Reisser CelineORCID1, 2, 3, Fasel Dominique2, Hurlimann Evelin2, Dukic Marinela4, Haag-Liautard Cathy2, Thuillier Virginie2, Galimov Yan5, Haag Christoph R.1, 2
Affiliation(s) 1 : CNRS Univ Montpellier Univ Paul Valery Montpellie, Ctr Ecol Fonct & Evolut CEFE UMR 5175, Montpellier, France.
2 : Univ Fribourg, Ecol & Evolut, Fribourg, Switzerland.
3 : IFREMER Centre du Pacifique, UMR 241 EIO, Labex CORAIL, BP 49, Taravao, Tahiti, Polynesie française
4 : Univ Basel, Inst Zool, Evolutionary Biol, Basel, Switzerland.
5 : Russian Acad Sci, Koltsov Inst Dev Biol, Moscow, Russia.
Source Molecular Biology And Evolution (0737-4038) (Oxford Univ Press), 2017-03 , Vol. 34 , N. 3 , P. 575-588
DOI 10.1093/molbev/msw251
WOS© Times Cited 11
Keyword(s) sex determination, sex chromosome, turnovers, gynodioecy, male sterility mutation, Daphnia magna
Abstract Sex chromosomes can evolve during the evolution of genetic sex determination (GSD) from environmental sex determination (ESD). Despite theoretical attention, early mechanisms involved in the transition from ESD to GSD have yet to be studied in nature. No mixed ESD-GSD animal species have been reported, except for some species of Daphnia, small freshwater crustaceans in which sex is usually determined solely by the environment, but in which a dominant female sex-determining locus is present in some populations. This locus follows Mendelian single-locus inheritance, but has otherwise not been characterized genetically. We now show that the sex-determining genomic region maps to the same low-recombining peri-centromeric region of linkage group 3 (LG3) in three highly divergent populations of D. magna, and spans 3.6 Mb. Despite low levels of recombination, the associated region contains signs of historical recombination, suggesting a role for selection acting on several genes thereby maintaining linkage disequilibrium among the 36 associated SNPs. The region carries numerous genes involved in sex differentiation in other taxa, including transformer2 and sox9. Taken together, the region determining the genetic females shows characteristics of a sex-related supergene, suggesting that LG3 is potentially an incipient W chromosome despite the lack of significant additional restriction of recombination between Z and W. The occurrence of the female-determining locus in a pre-existing low recombining region illustrates one possible form of recombination suppression in sex chromosomes. D. magna is a promising model for studying the evolutionary transitions from ESD to GSD and early sex chromosome evolution.
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Reisser Celine, Fasel Dominique, Hurlimann Evelin, Dukic Marinela, Haag-Liautard Cathy, Thuillier Virginie, Galimov Yan, Haag Christoph R. (2017). Transition from Environmental to Partial Genetic Sex Determination in Daphnia through the Evolution of a Female-Determining Incipient W Chromosome. Molecular Biology And Evolution, 34(3), 575-588. Publisher's official version : , Open Access version :