Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis

Type Article
Date 2018-05
Language English
Author(s) El-Demerdash AmrORCID1, 2, Moriou Celine1, Toullec Jordan3, Besson Marc4, 5, Soulet Stephanie6, Schmitt Nelly6, Petek Sylvain3, Lecchini David4, Debitus Cecile3, Al-Mourabit Ali1
Affiliation(s) 1 : Univ Paris Saclay, Univ Paris Sud, CNRS, UPR 2301,Inst Chim Subst Nat, 1 Ave Terrasse, F-91198 Gif Sur Yvette, France.
2 : Mansoura Univ, Div Organ Chem, Dept Chem, Fac Sci, Mansoura 35516, Egypt.
3 : UBO, IFREMER, IUEM, LEMAR,IRD,CNRS, F-29280 Plouzane, France.
4 : PSL Res Univ, CNRS, CRIOBE, EPHE,UPVD, F-98729 Moorea, French Polynesi, France.
5 : Univ Pierre & Marie Curie Paris, Observ Oceanol Banyuls Sur Mer, F-66650 Banyuls Sur Mer, France.
6 : UPF, EIO, ILM, IFREMER,IRD, F-98702 Tahiti, French Polynesi, France.
Source Marine Drugs (1660-3397) (Mdpi), 2018-05 , Vol. 16 , N. 5 , P. 146 (16p.)
DOI 10.3390/md16050146
WOS© Times Cited 15
Keyword(s) brominated tyrosine alkaloids, Suberea ianthelliformis, cytotoxicity, acetylcholinesterase inhibition

Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively.

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El-Demerdash Amr, Moriou Celine, Toullec Jordan, Besson Marc, Soulet Stephanie, Schmitt Nelly, Petek Sylvain, Lecchini David, Debitus Cecile, Al-Mourabit Ali (2018). Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis. Marine Drugs, 16(5), 146 (16p.). Publisher's official version : , Open Access version :