Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme

Type Article
Date 2014-08
Language English
Author(s) Delzor Aurelie1, 2, Couratier Philippe1, 2, 3, Boumediene Farid1, 2, Nicol Marie1, 2, 3, Druet-Cabanac Michel1, 2, 3, Paraf Francois3, Mejean Annick4, Ploux Olivier4, Leleu Jean-Philippe1, 2, Brient Luc5, Lengronne Marion5, Pichon Valerie6, 7, Combes Audrey6, 7, El Abdellaoui Saida6, 7, Bonneterre Vincent8, Lagrange Emmeline9, Besson Gerard9, Bicout Dominique J.8, 10, Boutonnat Jean9, Camu William11, 12, Pageot Nicolas11, 12, Juntas-Morales Raul11, 12, Rigau Valerie11, 12, Masseret EstelleORCID13, Abadie EricORCID14, Preux Pierre-Marie1, 2, 3, Marin Benoit1, 2
Affiliation(s) 1 : INSERM, UMR 1094, Trop Neuroepidemiol, Limoges, France.
2 : Univ Limoges, Sch Med, Inst Neuroepidemiol & Trop Neurol, CNRS,FR GIEST 3503, Limoges, France.
3 : Univ Hosp Dupuytren, Dept Neurol, ALS Ctr, Limoges, France.
4 : Univ Paris Diderot Paris 7, CNRS UMR 8236, Interdisciplinary Lab Tomorrows Energy Pack LIED, Paris, France.
5 : Univ Rennes 1, Ecosyst Biodivers Evolut, ECOBIO, UMR 6553, Rennes, France.
6 : ParisTech, CNRS CBI 8231, Dept Analyt Bioanalyt Sci & Miniaturizat LSABM, UMR ESPCI, Paris, France.
7 : UPMC, Univ Sorbonne, Paris, France.
8 : UJF Grenoble 1, UMR 5525, CNRS TIMC IMAG, Environm & Hlth Predict Populat EPSP, Grenoble, France.
9 : Univ Hosp Grenoble, Dept Neurol, Grenoble, France.
10 : VetAgro Sup, Environm & Hlth Predict Populat EPSP, Biomath & Epidemiol, Marcy Letoile, France.
11 : INSERM, Neurosci Inst, UMR 1051, Motoneuron Dis Neuroinflammat & Therapy, Montpellier, France.
12 : Univ Hosp Gui Chauliac, ALS Ctr, Dept Neurol, Montpellier, France.
13 : Univ Montpellier II, CNRS IRD Ifremer UM1 UM2, Ecol Coastal Marine Syst, ECOSYM,UMR 5119, Montpellier, France.
14 : Ifremer, Environm Resources Lab Languedoc Roussillon, Sete, France.
Source Bmj Open (2044-6055) (Bmj Publishing Group), 2014-08 , Vol. 4 , N. 8 , P. e005528 (14p.)
DOI 10.1136/bmjopen-2014-005528
WOS© Times Cited 17

Introduction: Amyotrophic lateral sclerosis (ALS) is the most common motor neurone disease. It occurs in two forms: (1) familial cases, for which several genes have been identified and (2) sporadic cases, for which various hypotheses have been formulated. Notably, the beta-N-methylamino-L-alanine (L-BMAA) toxin has been postulated to be involved in the occurrence of sporadic ALS. The objective of the French BMAALS programme is to study the putative link between L-BMAA and ALS. Methods and analysis: The programme covers the period from 1 January 2003 to 31 December 2011. Using multiple sources of ascertainment, all the incident ALS cases diagnosed during this period in the area under study (10 counties spread over three French regions) were collected. First, the standardised incidence ratio will be calculated for each municipality under concern. Then, by applying spatial clustering techniques, overincidence and underincidence zones of ALS will be sought. A casecontrol study, in the subpopulation living in the identified areas, will gather information about patients' occupations, leisure activities and lifestyle habits in order to assess potential risk factors to which they are or have been exposed. Specimens of drinking water, food and biological material (brain tissue) will be examined to assess the presence of LBMAA in the environment and tissues of ALS cases and controls. Ethics and dissemination: The study has been reviewed and approved by the French ethical committee of the CPP SOOM IV (Comite de Protection des Personnes Sud-Ouest & Outre-Mer IV). The results will be published in peer-reviewed journals and presented at national and international conferences.

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Delzor Aurelie, Couratier Philippe, Boumediene Farid, Nicol Marie, Druet-Cabanac Michel, Paraf Francois, Mejean Annick, Ploux Olivier, Leleu Jean-Philippe, Brient Luc, Lengronne Marion, Pichon Valerie, Combes Audrey, El Abdellaoui Saida, Bonneterre Vincent, Lagrange Emmeline, Besson Gerard, Bicout Dominique J., Boutonnat Jean, Camu William, Pageot Nicolas, Juntas-Morales Raul, Rigau Valerie, Masseret Estelle, Abadie Eric, Preux Pierre-Marie, Marin Benoit (2014). Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme. Bmj Open, 4(8), e005528 (14p.). Publisher's official version : , Open Access version :