Glucagon-like peptide-1 secretagogues from the leaves of Oparanthus teikiteetinii

Type Article
Date 2019-04
Language English
Author(s) Huguet Clement1, Olatunji Opeyemi Joshua1, 4, Real Eleonore2, Raharivelomanana Phila3, Urbain Aurelie1
Affiliation(s) 1 : Univ Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France.
2 : Univ Strasbourg, CNRS, LBP UMR 7021, F-67000 Strasbourg, France.
3 : Univ Polynesie Francaise, EIMS UMR 241 EIO, F-98702 Faaa Tahiti, French Polynesi, France.
4 : Prince Songkla Univ, Fac Tradit Thai Med, Hat Yai 90112, Thailand.
Source Phytochemistry Letters (1874-3900) (Elsevier Science Bv), 2019-04 , Vol. 30 , P. 201-204
DOI 10.1016/j.phytol.2019.02.020
Keyword(s) Oparanthus teikiteetinii, Benzofuran derivatives, Coumaran, Sesquiterpene lactones, Glucagon-like peptide-1 secretion
Abstract

In our search for natural compounds that stimulate glucagon-like peptide-1 secretion, an extract from the leaves of Oparanthus teikiteetinii (Asteraceae) was found to increase significantly GLP-1 secretion in vitro in a model cell line (mouse intestinal STC-1 cells). The phytochemical investigation of this extract resulted in the isolation of two new dihydrobenzofuran derivatives (1-2) identified as (2R)-2-(prop-1-en-2-yl)-2,3-dihydro-1-benzofuran-5-ol (1) and (2S,3R)-2-(prop-1-en-2-yl)-2,3-dihydro-1-benzofuran-3,5-diol (2). Thirteen other compounds were isolated, including eight known dihydrobenzofuran derivatives (3-10), jasopyran (11), and four sesquiterpene lactones (12-15) including a new one, grandulin (15). Their structures were established mainly by NMR and HRESIMS analysis and by comparison with data reported in the literature. Tested on STC-1 cells at the concentration of 100 mu M, compounds 7, 11, and 12 increased GLP-1 secretion by 305, 218, and 156% respectively, compared to control cells, without affecting cell viability.

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