Human Shellfish Poisoning: Implementation of a National Surveillance Program in France

Type Article
Date 2023-01
Language English
Author(s) Sinno-Tellier Sandra1, Abadie EricORCID2, Guillotin Sophie3, Bossée Anne4, Nicolas Marina5, Delcourt Nicolas3, 6
Affiliation(s) 1 : ANSES (French Agency for Food, Environmental and Ocupational Health and Safety, Maisons Alfort, France
2 : French Research Institute for Exploitation of the Sea (IFREMER), Biodivenv, Le Robert, France
3 : Poison Control Centre, Toulouse University Hospital, Toulouse, France
4 : Chemical, Biological, Radiological and Nuclear (CBRN) Defence, Analytical Chemistry Department, French Defense Procurement Agency (DGA), Vert-le-Petit, France
5 : Laboratory for Food Safety, ANSES (French Agency for Food, Environmental and Occupational Health and Safety), Maisons-Alfort, France
6 : INSERM UMR 1214, Toulouse NeuroImaging Center, Toulouse, France
Source Frontiers In Marine Science (2296-7745) (Frontiers Media), 2023-01 , Vol. 9 , P. 1089585. (9p.)
DOI 10.3389/fmars.2022.1089585
WOS© Times Cited 2
Keyword(s) shellfish poisoning, monitoring program, human exposure, harmful algae, phycotoxin

oxic algae and their toxins represent an emerging public health issue, particularly due to global warming. The toxicological mechanisms of neurotoxic phycotoxins and their human health effects have been widely described (paralytic, neurological, amnesic, and ciguateric toxins). Food poisoning by bivalve shellfish (mussels, oysters...) can cause serious or even fatal neurological disorders, due to the accumulation in their flesh of natural toxins that develop in the water that surrounds them. However, retrospective study of human shellfish poisoning highlighted the difficulties in identifying cases related to neurotoxic phycotoxins by gathering clinical and biological diagnostic confirmations on the one hand, as well as environmental contaminations on the other. To improve the collection of shellfish poisoning data, the French Agency for Food, Environmental and Occupational Health and Safety (ANSES), French Poison Control Centers (PCCs), the French Research Institute for Exploitation of the Sea (Ifremer) and the French Defense Procurement Agency (DGA)have developed a prospective surveillance of neurotoxins from algal origin that combines monitoring of poisoning cases (clinical monitoring), of harmful algae and their toxins in shellfish production areas (environmental monitoring), as well as of toxins levels in seafood leftovers and in biological samples from poisoned subjects. This original clinical and environmental monitoring will allow us to have a more complete view of phycotoxin human exposures that are underreported, and to implement measures to protect consumers.

Full Text
File Pages Size Access
Publisher's official version 14 1 MB Open access
Supplementary Material 662 KB Open access
Top of the page