Anti-Biofilm Activity of a Hyaluronan-like Exopolysaccharide from the Marine Vibrio MO245 against Pathogenic Bacteria
| Type | Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Date | 2022-11 | ||||||||
| Language | English | ||||||||
| Author(s) | Champion Marie 1, Portier Emilie1, Vallee-Rehel Karine1, Linossier Isabelle1, Balnois Eric2, Vignaud Guillaume3, Moppert Xavier4, Hellio Claire5, Fay Fabienne1 |
||||||||
| Affiliation(s) | 1 : Laboratoire de Biotechnologies et Chimie Marines, EA3884, Université Bretagne Sud, 56321 Lorient, France 2 : Laboratoire de Biotechnologies et Chimie Marines, EA3884, Université de Bretagne Occidentale, 29000 Quimper, France 3 : Institut de Recherche Dupuy de Lôme (IRDL), UMR CNRS 6027, Université Bretagne Sud, 56321 Lorient, France 4 : Pacific Biotech, BP 140 289, 98701 Arue, France 5 : Biodimar, LEMAR UMR6539, Institut Européen de la Mer, Université Bretagne Occidentale, 29238 Brest, France |
||||||||
| Source | Marine Drugs (Mdpi), 2022-11 , Vol. 20 , N. 11 , P. 728 (22p.) | ||||||||
| DOI | 10.3390/md20110728 | ||||||||
| WOS© Times Cited | 4 | ||||||||
| Note | This article belongs to the Collection Marine Polysaccharide | ||||||||
| Keyword(s) | exopolysaccharide, anti-adhesive activity, anti-biofilm activity, marine bacteria, non biocidal agent, Pseudomonas aeruginosa, Vibrio harveyi | ||||||||
| Abstract | Biofilms, responsible for many serious drawbacks in the medical and marine environment, can grow on abiotic and biotic surfaces. Commercial anti-biofilm solutions, based on the use of biocides, are available but their use increases the risk of antibiotic resistance and environmental pollution in marine industries. There is an urgent need to work on the development of ecofriendly solutions, formulated without biocidal agents, that rely on the anti-adhesive physico-chemical properties of their materials. In this context, exopolysaccharides (EPSs) are natural biopolymers with complex properties than may be used as anti-adhesive agents. This study is focused on the effect of the EPS MO245, a hyaluronic acid-like polysaccharide, on the growth, adhesion, biofilm maturation, and dispersion of two pathogenic model strains, Pseudomonas aeruginosa sp. PaO1 and Vibrio harveyi DSM19623. Our results demonstrated that MO245 may limit biofilm formation, with a biofilm inhibition between 20 and 50%, without any biocidal activity. Since EPSs have no significant impact on the bacterial motility and quorum sensing factors, our results indicate that physico-chemical interactions between the bacteria and the surfaces are modified due to the presence of an adsorbed EPS layer acting as a non-adsorbing layer. | ||||||||
| Full Text |
|