Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicans

Type Article
Date 2023-12
Language English
Author(s) Marquis MélanieORCID1, 2, Musino Dafne1, Gemin Valentin1, Kolypczuk LaetitiaORCID3, Passerini DelphineORCID3, Capron Isabelle1
Affiliation(s) 1 : INRAE, UR1268 Biopolymers Interactions and Assemblies, 44300 Nantes, France
2 : Oniris, INRAE, UMR0703 Physiopathologie Animale et BioThérapie du muscle et du système nerveux, 44307 Nantes, France
3 : Ifremer, MASAE Microbiologie Aliment Santé Environnement, 44000 Nantes, France
Source Carbohydrate Polymer Technologies And Applications (2666-8939) (Elsevier BV), 2023-12 , Vol. 6 , P. 100405 (9p.)
DOI 10.1016/j.carpta.2023.100405
Keyword(s) Cellulose nanocrystal (CNC), Chitin nanocrystal (ChiNC), Hybrid, Microfluidic, Hydrogel, Antimicrobial activities

Nanoparticles (NPs), offering high specific surface, are considered as the best potential anti-microbial agents for a wide range of medical nanotechnology. Among them, silver NPs (AgNPs) allow high biocidal activity. A design of ecological capsules is proposed where AgNPs of 22 nm in diameter are grafted on the surface of biobased nanocrystals obtained from cellulose (CNC) and chitin (ChiNC). These silver nanohybrids are dispersed in calcium-alginate microgels of 45–50 µm in diameter using microfluidic tools. Such double level of immobilization of AgNPs leads to highly stable carriers, prolongs shelf life and raises bioactivity, with a precise control of well dispersed AgNPs as determined by scanning transmission electron microscopy, UV-Vis spectroscopy and atomic absorption spectroscopy. Preliminary tests for antimicrobial activities of these new microgels have shown a significant inhibitory effect on Candida albicans, the most common fungal pathogen, responsible for thrush and vaginal yeast infections, for very low levels of silver.

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Marquis Mélanie, Musino Dafne, Gemin Valentin, Kolypczuk Laetitia, Passerini Delphine, Capron Isabelle (2023). Alginate microgels encapsulation strategy of silver nanoparticles active against Candida albicans. Carbohydrate Polymer Technologies And Applications, 6, 100405 (9p.). Publisher's official version : , Open Access version :