Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering

Type Article
Date 2011-09
Language English
Author(s) Senni Karim2, Pereira Jessica3, Gueniche Farida4, Delbarre-Ladrat ChristineORCID1, Sinquin CorinneORCID1, Ratiskol Jacqueline1, Godeau Gaston4, Fischer Anne-Marie3, 5, Helley Dominique3, 5, Colliec-Jouault SylviaORCID1
Affiliation(s) 1 : IFREMER, Lab Biotechnol & Marine Mol, F-44311 Nantes 03, France.
2 : Seadev FermenSys SAS, F-29280 Plouzane, France.
3 : Univ Paris 05, UMR S765, Fac Pharm, INSERM,U765, F-75006 Paris, France.
4 : Paris Descartes Univ, Dept Biochem, Fac Dent Surg, F-92120 Montrouge, France.
5 : Hop Europeen Georges Pompidou, AP HP, Biol Hematol Dept, F-75015 Paris, France.
Source Marine Drugs (1660-3397) (Mdpi Ag), 2011-09 , Vol. 9 , N. 9 , P. 1664-1681
DOI 10.3390/md9091664
WOS© Times Cited 144
Keyword(s) marine bacteria, marine algae, exopolysaccharides, sulfated polysaccharides, structure, chemical modification, biological activity, blue biotechnology, cell therapy, tissue engineering
Abstract The therapeutic potential of natural bioactive compounds such as polysaccharides, especially glycosaminoglycans, is now well documented, and this activity combined with natural biodiversity will allow the development of a new generation of therapeutics. Advances in our understanding of the biosynthesis, structure and function of complex glycans from mammalian origin have shown the crucial role of this class of molecules to modulate disease processes and the importance of a deeper knowledge of structure-activity relationships. Marine environment offers a tremendous biodiversity and original polysaccharides have been discovered presenting a great chemical diversity that is largely species specific. The study of the biological properties of the polysaccharides from marine eukaryotes and marine prokaryotes revealed that the polysaccharides from the marine environment could provide a valid alternative to traditional polysaccharides such as glycosaminoglycans. Marine polysaccharides present a real potential for natural product drug discovery and for the delivery of new marine derived products for therapeutic applications.
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Senni Karim, Pereira Jessica, Gueniche Farida, Delbarre-Ladrat Christine, Sinquin Corinne, Ratiskol Jacqueline, Godeau Gaston, Fischer Anne-Marie, Helley Dominique, Colliec-Jouault Sylvia (2011). Marine Polysaccharides: A Source of Bioactive Molecules for Cell Therapy and Tissue Engineering. Marine Drugs, 9(9), 1664-1681. Publisher's official version : , Open Access version :