Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection
Type | Article |
---|---|
Date | 2022-06 |
Language | English |
Author(s) | Fallet Manon7, Montagnani Caroline1, Petton Bruno2, Dantan Luc7, de Lorgeril Julien1, 3, Comarmond Sébastien7, Chaparro Cristian7, Toulza Eve7, Boitard Simon4, Escoubas Jean Michel8, Vergnes Agnes1, Le Grand Jacqueline2, Bulla Ingo7, Gueguen Yannick1, 5, Vidal-Dupiol Jeremie1, Grunau Christoph7, Mitta Guillaume6, 7, Cossau Céline7 |
Affiliation(s) | 1 : IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France 2 : Ifremer, UBO CNRS IRD, LEMAR UMR 6539, Argenton, France 3 : Ifremer, IRD, Univ Nouvelle-Calédonie, Univ La Réunion, ENTROPIE, F-98800, Nouméa, Nouvelle-Calédonie, France 4 : CBGP, CIRAD, INRAE, Institut Agro, IRD, Université de Montpellier, Montpellier, France 5 : MARBEC, CNRS, Ifremer, IRD, Univ Montpellier, Sète, France 6 : Ifremer, UMR 241 Écosystèmes Insulaires Océaniens, Labex Corail, Centre Ifremer du Pacifique, BP 49, 98725, Tahiti, French Polynesia 7 : IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France 8 : IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France |
Source | Microbiome (2049-2618) (BMC), 2022-06 , Vol. 10 , N. 1 , P. 85 (21p.) |
DOI | 10.1186/s40168-022-01280-5 |
WOS© Times Cited | 19 |
Keyword(s) | Oyster, Aquaculture, Microbiota, Innate immune shaping, Epigenetic, DNA methylation |
Abstract | Background The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation – and, importantly, protection from infectious disease – is still an open question. Results Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific Oyster Mortality Syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS. Conclusions We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease. |
Full Text |